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The Benefits of the Latest Migraine Clinical Trials

April 5, 2023
The Benefits of the Latest Migraine Clinical Trials
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The advancements in migraine treatment over the past few years have led to more options for managing pain, including new drugs with faster and fewer side effects, and innovative neuromodulation devices.

Clinical trials are exploring the potential of these treatments, including electric stimulation devices, to provide relief from migraine symptoms. It is important to seek the expertise of a headache specialist, such as a neurologist, to stay informed of the latest developments and determine the best course of action.

Participating in clinical studies can advance the field of migraine research and potentially benefit individuals suffering from migraines. This includes pediatric patients, those with episodic migraine, post-traumatic headaches, and cluster headaches.

The primary purpose of these trials is to test the efficacy and safety of new treatments in comparison to existing treatments and/or placebo, using diagnostic criteria, on both patient and healthy volunteer populations.

We encourage those who suffer from migraines to take an active role in their treatment and consider participating in clinical studies. By doing so, you can help advance the field of migraine research and potentially benefit from new and innovative treatments.

Stay informed about the latest advancements in migraine clinical studies and take the first step towards better pain management. Read on to learn more about the benefits of participating in these trials.

Acute Medications for the Prevention of Migraine

Acute medicines are made to stop migraine attacks. Most of the time, it’s best to take them as soon as you notice symptoms. The newest acute medication includes:

5-HT1f Drugs

5-HT1f drugs are a type of medication that is used to treat migraines. They work by targeting specific receptors in the brain known as 5-HT1f receptors. These drugs help to reduce the severity of migraines by decreasing the release of certain chemicals in the brain that contribute to headache disorders. Some 5-HT1f drugs also have anti-inflammatory effects, which can further reduce chronic migraine symptoms. These drugs are typically administered orally, and some are also available as nasal sprays.

Common examples of 5-HT1f drugs for migraine include sumatriptan, rizatriptan, and zolmitriptan. It is important to note that these drugs should only be used under the supervision of a doctor, as they may have potential side effects and interactions with other medications.

CGRP Receptor Blockers

CGRP receptor blockers are medication for migraine treatment. They block the impact of CGRP, a molecule that triggers migraine headaches by increasing blood flow and causing inflammation. By blocking CGRP, these drugs reduce migraine frequency and severity. They come in the form of injections or infusions and generally have few side effects. Erenumab, fremanezumab, and galcanezumab are common examples of CGRP receptor blockers. It's important to seek medical advice before using these drugs as they are relatively new and may not be suitable for everyone.

GRP Monoclonal Antibodies

CGRP monoclonal antibodies are a medication used to treat migraines by neutralizing CGRP, a molecule in the brain that contributes to migraine development. They are administered through injections or infusions and generally have minimal side effects. Common examples include erenumab, fremanezumab, and galcanezumab. However, they are relatively new drugs and must be used under the supervision of a doctor, who will determine the best treatment plan based on individual needs and health history.

Devices for Migraine Relief

Migraines can be a debilitating condition, but there is hope for relief. Advances in treatment options have made it possible for patients to effectively manage symptoms and reduce the frequency of attacks. It is important to seek the advice of a doctor to determine the best course of acute treatment for individual needs and health history.


Neuromodulation involves using electrical current to alter the activity of the nervous system and is used to treat migraines by reducing pain and symptoms. Different types of neuromodulation devices target specific nerves involved in migraine pain and work by changing the release of neurotransmitters. It is best used in conjunction with other treatments, and a doctor should be consulted for personalized treatment.

Trigger Point Injections

Trigger point injections target and reduce muscle tension and pain in the neck, head, and face. Migraines are often associated with tender points or trigger points in the muscles, which can cause pain when pressed. These injections contain a mixture of local anesthetic and a corticosteroid, which are delivered directly into the trigger points to relieve pain and improve muscle function. By reducing muscle tension, trigger point injections can help to prevent migraines or reduce their frequency and severity. However, it is important to note that trigger point injections should only be performed by a qualified medical professional, and their effectiveness may vary for each individual.

SPG Nerve Block

The SPG (sphenopalatine ganglion) nerve block is a procedure that injects a local anesthetic into the sphenopalatine ganglion to relieve migraine pain. It has been shown to effectively reduce the frequency and intensity of migraines and is considered safe and well-tolerated. The procedure should be performed by a specialized doctor, such as a headache specialist or pain management doctor.

The Benefits of the Latest Migraine Clinical Trials

Lifestyle Changes That Help Against Migraine

Recent advancements in migraine research have emphasized the significance of lifestyle modifications in chronic migraine management. Three key factors play a crucial role in controlling migraine headaches.

Get Enough Sleep

Sleep plays a crucial role in managing migraines as it regulates the circadian rhythm, which can trigger migraines if disrupted. Getting regular, adequate sleep can reduce stress levels and improve physical and mental health, reducing the risk of migraines. Aiming for 7-9 hours of sleep each night and maintaining a consistent sleep schedule is important for preventing migraines.

Eat the Right Food

Eating a balanced diet and avoiding trigger foods can help manage migraines. Common food triggers include processed foods, artificial additives, tyramine-rich foods, and nitrates in preserved meats. Staying hydrated and eating regular, balanced meals can also prevent migraines. Keeping a food diary and working with a doctor or dietitian can help determine individual triggers and develop a healthy eating plan.

Exercise Frequently

Exercise helps with migraines by improving circulation, reducing stress, regulating sleep, and increasing endorphins which are natural pain-relievers. However, it should be done in moderation as over-exertion can trigger migraines. Consult a doctor before starting an exercise regimen if you have a history of migraines.

Santos Research Center is Enrolling Participants for Migraine Clinical Trials 2023

If you think you may have migraines or migraine-related pain, you may want to investigate the paid clinical trial in Tampa.

These trials are open to a large age range and offer several benefits.

Contact Us Today!

Santos Research Center in Tampa is open to eligible participants in our ongoing research on new medical interventions to treat migraine.

If you are interested in Paid Medical Trials at Santos Research Center, please contact us at (813) 249-9100 or visit us at 5927 Webb Rd Tampa FL 33615.

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Santos Research Center, Corp. is a research facility conducting paid clinical trials, in partnership with major pharmaceutical companies & CROs. We work with patients from across the Tampa Bay area.

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